World-renowned cartographer of the brain, Scientia Professor George Paxinos, Conjoint Professor at UNSW, has discovered a hidden region of the human brain. The region is found near the brain-spinal cord junction and Professor Paxinos has named it the Endorestiform Nucleus.

Professor Paxinos, from Neuroscience Research Australia (NeuRA), suspected the existence of the Endorestiform Nucleus 30 years ago but has only now been able to see it due to better staining and imaging techniques. Commenting on this discovery, Professor Paxinos says it can be likened to finding a new star.


“The region is intriguing because it seems to be absent in the rhesus monkey and other animals that we have studied,” said Professor Paxinos, adding, “there have to be some things that are unique about the human brain besides its larger size, and the Endorestiform Nucleus may be one of them.”


The Endorestiform Nucleus is located within the inferior cerebellar peduncle, an area that integrates sensory and motor information to refine our posture, balance and fine motor movements.


“I can only guess as to its function, but given the part of the brain where it has been found, it might be involved in fine motor control,” says Professor Paxinos.


The discovery of the region may help researchers explore cures for diseases including Parkinson’s disease and motor neuron disease.


Neuroscientists researching neurological or psychiatric diseases use Professor Paxinos’s maps to guide their work. Professor Paxinos’s brain atlases are heralded as the most accurate for the identification of brain structures and are also used in neurosurgery.


An increasingly detailed understanding of the architecture and connectivity of the nervous system has been central to most major discoveries in neuroscience in the past 100 years.


“Professor Paxinos’s atlases showing detailed morphology and connections of the human brain and spinal cord, provide a critical framework for researchers to test hypotheses from synaptic function to treatments for diseases of the brain,” said Professor Peter Schofield, CEO at NeuRA.


Professor Paxinos is the author of the most cited publication in neuroscience and another 52 books of highly detailed maps of the brain. The maps chart the course for neurosurgery and neuroscience research, enabling exploration, discovery and the development of treatments for diseases and disorders of the brain.


The discovery of the Endorestiform Nucleus is detailed in Professor Paxinos's latest book titled Human Brainstem: Cytoarchitecture, Chemoarchitecture, Myeloarchitecture.

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Original story by University of New South Wales